EXIA2: Web Server of Accurate and Rapid Protein Catalytic Residue Prediction

Table 2

Comparison of prediction performance of EXIA2 web server and CRpred, POOL, ConSurf, and ResBoost.

Competing method	CRpred	POOL^1	POOL^2	ConSurf^3	ResBoost^3
Benchmark datasets	EF fold	POOL160	POOL160	P100	P100
Recall (R)	48.2	61.7	64.7	55.0	55.0
Precision (P)	17.0	18.1	19.1	5.0	17.0
AUCROC^4	—	0.907	0.925	—	—
EXIA2 + PSSM^5
Recall at equal P	72.7	80.0	77.8	96.0	74.3
Precision at equal R	27.3	24.3	23.3	25.3	25.3
AUCROC	0.968	0.965	0.965	0.966	0.966
EXIA2^6
Recall at equal P	45.1	70.8	68.6	90.6	58.0
Precision at equal R	16.2	22.2	20.8	18.3	18.3
AUCROC	0.943	0.960	0.960	0.952	0.952

Prediction results of POOL.
²Prediction results of POOL combined with evolutionary information.
³Prediction results published in [40]. Complete comparison of ROC and recall-precision curves is available in supplementary Figure S4.
⁴Some AUC values are not available in the publications.
⁵Prediction results of EXIA2 combined with PSI-Blast PSSM.
⁶Prediction results of EXIA2 without evolutionary information.