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BioMed Research International
/
2014
/
Article
/
Tab 1
/
Review Article
Adjuvant Cardioprotection in Cardiac Surgery: Update
Table 1
Overview of ongoing major clinical studies in pharmacological cardioprotection.
Agent
Property
Clinical trial
Reference
Cyclosporine
mPTP inhibitor
CIRCUS trial:
NCT01502774
[
103
]
TRO40303
mPTP inhibitor
MITOCARE:
NCT01374321
[
104
]
Bendavia
mPTP inhibitor
EMBRACE:
NCT01572909
[
105
]
Mecasermin
IGF analogue
RESUS-AMI:
NCT01438086
[
106
]
Mangafodipir
Iron oxidation inhibitor and chelator
MANAMI:
NCT00966563
[
107
]
Melatonin
Multimodal effects
MARIA:
NCT00640094
[
108
]
Inhaled Nitric Oxide
Vasodilator, mPTP inhibitor
NOMI:
NCT01398384
[
109
]
IV sodium nitrite
Vasodilator, mPTP inhibitor
NIAMI:
NCT01388504
[
110
]
Intracoronary sodium nitrite
Vasodilator, mPTP inhibitor
NITRITE-AMI:
NCT01584453
[
111
]
Thymosin beta-4
Growth regulator
NCT00378352
[
112
]
Metoprolol
-blocker
METOCARD-CNIC:
NCT01311700
[
113
]