Review Article
Magnetic Resonance Spectroscopy in the Diagnosis of Dementia with Lewy Bodies
Table 1
1H-MRS studies in DLB (modified after Watson et al. [
23]).
| | Author and reference | Subjects | Area (voxel of interest) | Metabolite ratios in DLB cases | | NAA/Cr | Cho/Cr | Glx/Cr | mI/Cr |
| | Molina et al. (2002) [32] | CTL () vs DLB () | WM: centrum semiovale
GM: parasagittal parietal cortex | ↓
↔ | ↓
↔ | ↓ ↔
↔ | NA
NA | | Kantarci et al. (2004) [33] | CTL () vs DLB () vs AD () | Right and left posterior cingulated gyrus and inferior precunei |
↔
| ↑ ↔ |
↔
|
↔
| | Magierski et al. (2004) [34] | CTL () vs DLB () vs AD () | Centrum semiovale, occipital grey matter and temporal lobes | ↓ | NA | NA |
↔
| | Xuan et al. (2008) [35] | CTL () vs DLB () | Bilateral hippocampi | ↓ |
↔
| NA | NA |
|
|
↔: Unchanged; ↓: reduced; ↑: increased; NA: not applicable; CTL: controls; AD: Alzheimer’s disease; DLB: dementia with Lewy bodies; WM: white matter; GM; grey matter.
|
