Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 810487, 7 pages
http://dx.doi.org/10.1155/2014/810487
Research Article

Oncogenic PIK3CA Mutation and Dysregulation in Human Salivary Duct Carcinoma

1The Department of Pathology, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA
2Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA
3The Department of Otolaryngology and Head and Neck Surgery, Columbia University Medical Center, 1130 Saint Nicholas Avenue, ICRC 10-04, New York, NY 10032, USA

Received 29 October 2013; Revised 12 December 2013; Accepted 21 December 2013; Published 8 January 2014

Academic Editor: Sandra B. Gabelli

Copyright © 2014 Wanglong Qiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Kleinsasser, H. J. Klein, and G. Hübner, “Salivary duct carcinoma: a group of salivary gland tumors analogous to mammary duct carcinoma,” Archiv für Klinische und Experimentelle Ohren-Nasen-und Kehlkopfheilkunde, vol. 192, no. 1, pp. 100–105, 1968. View at Google Scholar · View at Scopus
  2. R. Delgado, F. Vuitch, and J. Albores-Saavedra, “Salivary duct carcinoma,” Cancer, vol. 72, no. 5, pp. 1503–1512, 1993. View at Google Scholar · View at Scopus
  3. R. Gal, M. Strauss, Y. Zohar, and E. Kessler, “Salivary duct carcinoma of the parotid gland: cytologic and histopathologic study,” Acta Cytologica, vol. 29, no. 3, pp. 454–456, 1985. View at Google Scholar · View at Scopus
  4. P. M. Speight and A. W. Barrett, “Salivary gland tumours,” Oral Diseases, vol. 8, no. 5, pp. 229–240, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. E. Lewis, B. C. McKinney, L. H. Weiland, J. A. Ferreiro, and K. D. Olsen, “Salivary duct carcinoma: clinicopathologic and immunohistochemical review of 26 cases,” Cancer, vol. 77, pp. 223–230, 1996. View at Google Scholar
  6. L. Barnes, U. Rao, J. Krause, L. Contis, A. Schwartz, and P. Scalamogna, “Salivary duct carcinoma. Part I: a clinicopathologic evaluation and DNA image analysis of 13 cases with review of the literature,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 78, no. 1, pp. 64–73, 1994. View at Google Scholar · View at Scopus
  7. D. T. Wee, A. A. Thomas, and P. J. Bradley, “Salivary duct carcinoma: what is already known, and can we improve survival?” Journal of Laryngology and Otology, vol. 126, supplement 2, pp. S2–S7, 2012. View at Google Scholar
  8. A. Prat, M. Parera, V. Reyes et al., “Successful treatment of pulmonary metastatic salivary ductal carcinoma with trastuzumab-based therapy,” Head and Neck, vol. 30, no. 5, pp. 680–683, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. H. W. Chang, M. Aoki, D. Fruman et al., “Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase,” Science, vol. 276, no. 5320, pp. 1848–1850, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Shayesteh, Y. Lu, W.-L. Kuo et al., “PlK3CA is implicated as an oncogene in ovarian cancer,” Nature Genetics, vol. 21, no. 1, pp. 99–102, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Garcia Pedrero, D. Garcia Carracedo, C. Muñoz Pinto et al., “Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma,” International Journal of Cancer, vol. 114, no. 2, pp. 242–248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Samuels and V. E. Velculescu, “Oncogenic mutations of PIK3CA in human cancers,” Cell Cycle, vol. 3, no. 10, pp. 1221–1224, 2004. View at Google Scholar · View at Scopus
  13. K. C. Bruckman, F. Schnleben, W. Qiu, V. L. Woo, and G. H. Su, “Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 110, no. 5, pp. 632–637, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Qiu, F. Schönleben, X. Li et al., “PIK3CA mutations in head and neck squamous cell carcinoma,” Clinical Cancer Research, vol. 12, no. 5, pp. 1441–1446, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Qiu, G.-X. Tong, S. Manolidis, L. G. Close, A. M. Assaad, and G. H. Su, “Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer,” International Journal of Cancer, vol. 122, no. 5, pp. 1189–1194, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Schönleben, W. Qiu, N. T. Ciau et al., “PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas,” Clinical Cancer Research, vol. 12, no. 12, pp. 3851–3855, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Schönleben, W. Qiu, H. E. Remotti, W. Hohenberger, and G. H. Su, “PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas,” Langenbeck's Archives of Surgery, vol. 393, no. 3, pp. 289–296, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. S. J. Isakoff, J. A. Engelman, H. Y. Irie et al., “Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells,” Cancer Research, vol. 65, no. 23, pp. 10992–11000, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. L. Shao, M. Rong, F. Grieu, and B. Iacopetta, “PIK3CA mutations in breast cancer are associated with poor outcome,” Breast Cancer Research and Treatment, vol. 96, no. 1, pp. 91–95, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Buttitta, L. Felicioni, F. Barassi et al., “PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma,” Journal of Pathology, vol. 208, no. 3, pp. 350–355, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Kang, A. G. Bader, and P. K. Vogt, “Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 3, pp. 802–807, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Cornolti, M. Ungari, M. L. Morassi et al., “Amplification and overexpression of Her2/neu gene and HER2/neu protein in salivary duct carcinoma of the parotid gland,” Archives of Otolaryngology, vol. 133, no. 10, pp. 1031–1036, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Jaehne, K. Roeser, T. Jaekel, J. David Schepers, N. Albert, and T. Löning, “Clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases,” Cancer, vol. 103, no. 12, pp. 2526–2533, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. V. Nardi, P. M. Sadow, D. Juric et al., “Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment,” Clinical Cancer Research, vol. 19, pp. 480–490, 2013. View at Google Scholar
  25. C. C. Griffith, R. R. Seethala, A. Luvison, M. Miller, and S. I. Chiosea, “PIK3CA mutations and PTEN loss in salivary duct carcinomas,” The American Journal of Surgical Pathology, vol. 37, pp. 1201–1207, 2013. View at Google Scholar
  26. S. Suzuki, Y. Dobashi, H. Minato, R. Tajiri, T. Yoshizaki, and A. Ooi, “EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas,” Virchows Archiv, vol. 461, no. 3, pp. 271–282, 2012. View at Google Scholar
  27. G. Wu, E. Mambo, Z. Guo et al., “Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 8, pp. 4688–4693, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Wu, M. Xing, E. Mambo et al., “Somatic mutation and gain of copy number of PIK3CA in human breast cancer,” Breast Cancer Research, vol. 7, no. 5, pp. R609–R616, 2005. View at Google Scholar · View at Scopus
  29. Y.-Y. Ma, S.-J. Wei, Y.-C. Lin et al., “PIK3CA as an oncogene in cervical cancer,” Oncogene, vol. 19, no. 23, pp. 2739–2744, 2000. View at Google Scholar · View at Scopus
  30. T. Goto, M. Takano, H. Sasa, H. Tsuda, K. Yamauchi, and Y. Kikuchi, “Clinical significance of immunocytochemistry for PIK3CA as a carcinogenesis-related marker on liquid-based cytology in cervical intraepithelial neoplasia,” Oncology reports, vol. 15, no. 2, pp. 387–391, 2006. View at Google Scholar · View at Scopus