A truncated, tumor-targeted human protein tissue factor (tTF RGD) to induce coagulation on binding to angiogenic receptors to heat specifically directed coagulation-cascade activation in tumours
“Signalling” modules (PEG-decorated gold nanorods, tumor-targeted truncated tissue factor proteins) that target tumors and then locally activate the coagulation cascade to broadcast tumor location to clot-targeted “receiving” nanoparticles in circulation that carry a diagnostic or therapeutic cargo (ironoxide nanoworms, doxorubicin-loaded liposomes)
In vivo MDA-MB-435 xenograft tumors, i.v. injection
Each nanohorn encapsulated within one immunoliposome formulated with PEG and thermally stable and pH sensitive phospholipids for pH sensitive and prolonged release of paclitaxel
SK-BR-3 and BT-20 breast cancer cells, in vitro cytotoxicity
RGD/integrin , a cell surface glycoprotein that is preferentially expressed in angiogenic endothelia
Albumin-based nanoconjugates with fluorescence labeling which are small, highly specific, and noncytotoxic
Tumor spheroids of A375/GFP cell, tumor spheroid study using A375/GFP cells to confirm the uptake and penetration of nanoconjugates in three-dimensional (3D) culture
Paclitaxel-ultrasmall HA (3–5 kDa) nanoconjugates internalized via CD44 receptor-mediated endocytosis, which allowed paclitaxel to bypass the P-glycoprotein- mediated efflux on the surface of cancer cells
Brain metastasis of breast cancer using MDA-MB-231Br breast cancer cells, i.v. injection
An assay for PSA detection with gold nanoparticles based on the PSA-specific Abs and short DNA sequences (barcodes)
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Prostate-specific antigen (PSA)
Magnetic microparticles conjugated with PSA-specific antibodies to extract trace amounts of the target analyte (PSA) in serum samples from patients and gold nanoparticles with PSA-specific antibodies and short DNA sequences (the barcodes) attached to detect this analyte
An ultrasensitive assay for prostate cancer, in vitro barcode array
Water soluble carbon nanotubes functionalized with PEG, radio labels, and RGD peptide
1–5 (diameter), 100–300 (length)
RGD/integrins
RGD-pegylated SWCNTs, radio-labelled SWCNTs
U87MG human glioblastoma and HT-29 human colorectal cancer cell lines, U87MG and HT-29 tumour xenograft models for biodistribution (PET), i.v. injection
Human/murine chimeric IgG1 mAb (TRC105)/both human and murine CD105
RGO conjugated to the anti-CD105 antibody TRC105
Tumor vasculature targeting and imaging in living mice as a theranostic agent, in vitro (4T1 murine breast cancer, MCF-7 human breast cancer, and human umbilical vein endothelial cells (HUVECs)), in vivo (4T1 breast cancer model), i.v. injection
