Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues

Table 2

Prediction of toxicity risk of the N-aryl-5-substituted-1,3,4-oxadiazol-2-amine analogues (4a–x).

Compound	Prediction of toxicity risk by Osiris
	MUT	IRRI	REP
4a	—	—	—
4b	—	—	—
4c	—	—	—
4d	—	—	—
4e	+	—	—
4f	—	—	+
4g	—	—	—
4h	—	—	—
4i	—	—	—
4j	—	—	—
4k	+	—	—
4l	—	—	+
4m	—	—	—
4n	—	—	—
4o	—	—	—
4p	—	—	—
4q	+	—	—
4r	—	—	—
4s	—	+^a	—
4t	—	+^a	—
4u	—	+^a	—
4v	—	+^a	—
4w	—	+^a	—
4x	—	+^a	—
Methotrexate	+^a	—	+^a
Fluorouracil	+	+	+

MUT: mutagenic, IRRI: irritant, REP: reproductive effect. A dash (—) indicates no effect, a plus (+) indicates the effect, and (+^a) indicates slight effect.