IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with Polymyositis/Dermatomyositis

Table 2

The associations between disease activity, serum cytokine levels, and ferritin levels.

	Global VAS, 𝑟𝑠	Pulmonary VAS, 𝑟𝑠
IL-1𝛽	−0.09	−0.03
IL-2	−0.01	0.06
IL-4	−0.04	0.31
IL-6	0.47**	0.33
IL-8	0.51**	0.45**
IL-10	0.50**	0.46**
IL-12	0.05	0.11
IL-13	−0.05	−0.01
IL-17	0.17	−0.05
IL-18	0.53**	0.34*
TNF-𝛼	0.39*	0.45**
IFN-α	−0.03	−0.03
IFN-𝛾	0.20	0.11
IP-10	0.44*	0.33*
Ferritin	0.50*	0.62***

Statistical analyses were performed using Spearman’s rank correlation coefficient.
𝑃 values are as indicated below. ^∗𝑃<0.05,  ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.
VAS: visual analogue scale and IP-10: interferon 𝛾-inducible 10-kd protein.