Niosomes of Ascorbic Acid and α-Tocopherol in the Cerebral Ischemia-Reperfusion Model in Male Rats
Figure 7
Electron micrograph of cortical neurons from (a) sham-operated, (b) empty noisome, (c) saline treated, (d) free ascorbic acid, (e) ascorbic noisome, (f) α-tocopherol noisome, and (g) niosomal formulation with a mixture of α-tocopherol and ascorbic acid treated rats. As shown in the micrograph, the normal ultrastructure of cortical neuron is visible in sham-operated group. Ischemia-reperfusion resulted in severe degenerative changes including chromatin aggregation, organelles swelling of the neurons in the saline-treated and empty niosome groups. Meanwhile, the whole ultrastructure of cortical neurons was maintained in the other groups mostly in the niosome formulation with a mixture of α-tocopherol and ascorbic acid. (Scale bar: 630 nm).
