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BioMed Research International
Volume 2014, Article ID 818107, 16 pages
Review Article

Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies

1Laboratorio Cellule Staminali, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Via F. Sforza 35, 20122 Milano, Italy
2Ystem s.r.l., Via Podgora 7, 20122 Milano, Italy

Received 27 January 2014; Revised 7 April 2014; Accepted 30 April 2014; Published 19 May 2014

Academic Editor: Fabio Rossi

Copyright © 2014 Andrea Farini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing the dystrophic muscle damage using gene transfer or cell therapy. Here we discussed current knowledge about involvement of immune system responses to experimental therapies in MDs.