Predicting Glycerophosphoinositol Identities in Lipidomic Datasets Using VaLID (Visualization and Phospholipid Identification)—An Online Bioinformatic Search Engine
Glycerophosphoinositol (PI) metabolism to PI phosphates (). (a) Metabolism of membrane PIs to bioactive second messengers. The molecular identity of each species, defined by carbon chain length and linkage to the glycerophospholipid backbone, is predicted to affect signalling specificity in addition to known effects of PI headgroup phosphorylation. (b) Phosphorylation of species regulates the localization of different PI-binding proteins and targets them to specific organelles (i.e., lipid-protein interaction). Phosphorylation status and carbon chain length dictate localization and likely restrict functions. Together, structural PIs and their second messengers regulate vesicular fusion, exocytosis, and endocytosis as reviewed in (and adapted from) [2, 3].