The Influence of Standardized Valeriana officinalis Extract on the CYP3A1 Gene Expression by Nuclear Receptors in In Vivo Model
Table 1
The effect of synthetic substances (DEX, KET) and Valeriana officinalis on expression level of analyzed genes in male rats ().
Substance
(mean% ± SEM%) 3 days
(mean% ± SEM%) 10 days
CYP3A1
DEX (50 mg/kg)
544.36 ± 34.07
<0.001
—
#
—
#
KET (10 mg/kg)
92.92 ± 4.07
0.3
81.97 ± 5.56
0.013
VAL (300 mg/kg)
65.37 ± 6.35
0.248
63.36 ± 6.66
<0.001
PXR
DEX (50 mg/kg)
118.72 ± 5.49
0.033
—
#
—
#
KET (10 mg/kg)
101.27 ± 4.31
0.879
105.52 ± 6.7
0.686
VAL (300 mg/kg)
103.66 ± 5.61
0.62
96.35 ± 5.77
0.62
CAR
DEX (50 mg/kg)
68.85 ± 4.74
0.16
—
#
—
#
KET (10 mg/kg)
97.14 ± 6.36
0.72
138.44 ± 17.71
0.044
VAL (300 mg/kg)
99.0 ± 4.94
0.837
146 ± 15.73
0.023
RXR
DEX (50 mg/kg)
117.79 ± 9.67
0.302
—
#
—
#
KET (10 mg/kg)
67.34 ± 8.4
0.061
60.63 ± 9.48
0.016
VAL (300 mg/kg)
71.39 ± 7.72
0.034
101.19 ± 7.27
0.917
GR
DEX (50 mg/kg)
77.54 ± 4.05
0.008
—
#
—
#
KET (10 mg/kg)
131.66 ± 5.68
0.002
82.88 ± 10.04
0.145
VAL (300 mg/kg)
103.63 ± 6.78
0.644
101.70 ± 7.21
0.859
HNF-4
DEX (50 mg/kg)
85.13 ± 9.46
0.196
—
#
—
#
KET (10 mg/kg)
99.77 ± 15.62
0.987
133.51 ± 7.65
0.047
VAL (300 mg/kg)
77.84 ± 3.92
0.005
67.94 ± 7.37
0.012
The control groups fed standard diet were defined as 100%. as compared with the control group (one-way ANOVA test). DEX: Dexamethasone; KET: ketoconazole; VAL: Valeriana officinalis. #No data.
