Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy

Figure 8

Cancer-targeted multimodality imaging through MFRAS1411 conjugated nanoparticles. Tumor-bearing mice were intravenously injected with MFR-AS1411 nanoparticles (b1) and MFR-AS1411mt (b2) nanoparticles (control group). Radionuclide images were performed at 1, 6, and 24 h after injection. Scintigraphic images of tumors in mice injected with MFRAS1411 exhibited that MFR-AS1411 nanoparticles were accumulated in the tumors but MFRAS1411mt were not. Tumor growth patterns were followed using bioluminescence signals acquired from luciferase-expressing C6 cells (a1, a2). MR images of tumor-bearing mice before (c1, d1) and after (c2, d2) injection of MFR-AS1411 were obtained. Dark signal intensities at tumor sites were detected in MFR-AS1411-injected mice (arrowhead) (adopted from Hwang et al. [73]).