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BioMed Research International
Volume 2014 (2014), Article ID 819360, 11 pages
Review Article

Multiparametric MRI-Targeted TRUS Prostate Biopsies Using Visual Registration

1Department of Radiology, Lille University Hospital, Lille University, 59000 Lille, France
2Inserm U703, 59120 Loos, France
3Department of Urology, Lille University Hospital, Lille University, 59000 Lille, France

Received 17 May 2014; Accepted 16 September 2014; Published 1 December 2014

Academic Editor: Barıs Turkbey

Copyright © 2014 Philippe Puech et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Prebiopsy multiparametric prostate MRI (mp-MRI), followed by transrectal ultrasound-guided (TRUS-G) target biopsies (TB) of the prostate is a key combination for the diagnosis of clinically significant prostate cancers (CSPCa), to avoid prostate cancer (PCa) overtreatment. Several techniques are available for guiding TB to the suspicious mp-MRI targets, but the simplest, cheapest, and easiest to learn is “cognitive,” with visual registration of MRI and TRUS data. This review details the successive steps of the method (target detection, mp-MRI reporting, intermodality fusion, TRUS guidance to target, sampling simulation, sampling, TRUS session reporting, and quality insurance), how to optimize each, and the global indications of mp-MRI-targeted biopsies. We discuss the diagnostic yield of visually-registered TB in comparison with conventional biopsy, and TB performed using other registration methods.