Metabolic Acidosis and Strong Ion Gap in Critically Ill Patients with Acute Kidney Injury

Table 1

Characteristics of the ICU patients with metabolic acidosis.

	Nonacute kidney injury (n = 38)	Acute kidney injury (n = 40)	P
Age (y)	67.3 ± 10.4	72.5 ± 17.9	0.120
Sex (M : F)*	18 : 20	22 : 18	0.5
WBC count	13152 ± 4364	17496 ± 10664	0.022
Hct	33.71 ± 5.52	32.28 ± 6.94	0.319
BUN	42.1 ± 18.6	91.7 ± 54.8	<0.0001
Cr	2.16 ± 0.91	5.73 ± 3.46	<0.0001
Glucose	213 ± 194	276.7 ± 257.0	0.219
Uric acid	7.39 ± 2.70	9.82 ± 3.56	0.001
Lactate	63.3 ± 42.2	67.3 ± 61.7	0.743
albumin	2.89 ± 0.57	2.95 ± 0.60	0.650
Bilirubin	2.02 ± 2.22	1.75 ± 2.58	0.623
Na (meq/L)	139.41 ± 4.8	142.03 ± 10.05	0.150
K (meq/L)	4.39 ± 0.77	5.04 ± 1.59	0.024
Cl (meq/L)	108.7 ± 6.4	104.4 ± 10.9	0.036
Ca (meq/L)	8.3 ± 0.5	7.8 ± 1.2	0.023
Mg (meq/L)	2.43 ± 0.48	2.81 ± 0.84	0.017
Phosphate (meq/L)	5.2 ± 1.4	7.2 ± 3.4	0.001
pH	7.219 ± 0.110	7.195 ± 0.152	0.417
PaCO2	31.96 ± 5.72	31.71 ± 11.14	0.903
PaO2	174.79 ± 92.57	121.63 ± 61.66	0.004
HCO3	14.73 ± 2.92	12.89 ± 4.66	0.041
SBE	−11.68 ± 3.88	−13.68 ± 6.31	0.098
APA II	24.3 ± 4.7	32.1 ± 7.2	<0.0001
APA IV	98 ± 17.7	112.5 ± 30.4	0.013
aSID	28.70 ± 4.94	34.75 ± 7.61	<0.0001
SIG	10.62 ± 3.20	17.15 ± 7.63	<0.0001
AG	15.63 ± 5.01	20.42 ± 9.51	0.007
CAG	11.65 ± 4.96	15.87 ± 9.21	0.015

∗Chi-square test.