Evaluation of the Efficacy of 50% Autologous Serum Eye Drops in Different Ocular Surface Pathologies

Table 1

Inclusion and exclusion criteria of the study.

Criteria	Inclusion criteria	Exclusion criteria
General		Inability of venous blood sampling because of; (i) venous access being not available,,; (ii) anemia,; (iii) cerebrovascular or cardiovascular disorders,; (iv) being positive for viral markers (HBV, HCV, and HIV),; (v) being bacterial active,; (vi) women who are pregnant or breast-feeding,; (vii) patients unable to provide informed consent,; (viii) age under 18 years.
Chemical eye burn	(i) Persistent epithelial defect; (ii) Inflammation and/or opacity and/or corneal neovascularization	(i) Corneal perforation/melting; (ii) Limbal stem cell deficit; (iii) Patients with active infections of the eye or eyelid; (iv) Abnormalities of the eyelid
Severe dry eye syndrome	(i) Symptoms of dry eye with daily activity limitation; (ii) Time to break-up <5 sec; (iii) Schirmer's test without anaesthesia <5 mm after 5 minutes; (iv) Fluorescein staining positive with or without epithelial defect; (v) Patients refractory to conventional therapy
Neurotrophic keratitis	(i) Patients with persistent epithelial defects; (ii) Patients refractory to conventional therapy

HBV = hepatitis B virus; HCV = hepatitis C virus; HIV = human immunodeficiency virus.