BioMed Research International / 2014 / Article / Tab 1

Review Article

Acknowledged Signatures of Matrix Metalloproteinases in Takayasu’s Arteritis

Table 1

Summary of the various MMPs and TIMPs and alterations in their levels in subjects with Takayasu’s arteritis.

SubgroupMMPs/TIMPsObservationsReference

CollagenasesMMP-1 (collagenase-1)N.S[17]
TA > C, A > R (mRNA)[44]
MMP-8 (collagenase-2)
MMP-13 (collagenase-3)
MMP-18 (collagenase-4)

GelatinasesMMP-2 (gelatinase-A)N.S[53]
TA > C, A > R (Activity)[14]
MMP-9 (gelatinase-B)A > C[46]
TA > C[17]
TA > C; A > R[47]
A > R > C[53]
TA > C, A > R (mRNA)[44]
TA > C, A > R (Activity)

StromelysinsMMP-3 (stromelysin 1)A > C[46]
N.S[17]
TA > C[47]
N.S[53]
TA > C, A > R (mRNA)[44]
MMP-10 (stromelysin 2)
MMP-11 (stromelysin 3)

MatrilysinsMMP-7 (matrilysin-1)
MMP-26 (matrilysin-2)

Membrane-type MMPsMMP-14, MMP-15, MMP-16, MMP-17, MMP-23, MMP-24, and MMP-25

Other MMPsMMP-12, MMP-19, MMP-20, MMP-22, and MMP-28

TIMPsTIMP1C > A[46]
TA > C, R > C[17]
C > TA[47]
TA > C, A versus R = N.S (mRNA)[44]
TIMP2
TIMP3
TIMP4

TA: total TA population; A: active; R: remission; C: controls; N.S: not significant.