Alterations in Lipid Mediated Signaling and Wnt/β-Catenin Signaling in DMH Induced Colon Cancer on Supplementation of Fish Oil

Figure 2

Alterations on the expression of COX-2 on administration of both of the ratios of fish oil and corn oil in experimentally induced colon cancer. (a) depicts band intensity in the initiation phase of different groups and (b) represents band intensity in postinitiation phase. (c) depicts quantitative analysis of COX-2 expression in the initiation and postinitiation phase. Lane 1-band intensity of control, 2-DMH treated, 3-FO+CO(1 : 1)+EDTA, 4-FO+CO(1 : 1)+DMH, 5-FO+CO(2.5 : 1)+EDTA, and 6-FO+CO(2.5 : 1)+DMH. The results are expressed as Mean ± S.D. for 𝑛=4. ^∗∗∗𝑃<0.001 with respect to control, ^∗∗𝑃<0.01 with respect to control, ^###𝑃<0.001 with respect to DMH, ^##𝑃<0.01 with respect to DMH, and ^†††𝑃<0.001 with respect to FO : CO(1 : 1) + DMH.

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