Hot-Stage Microscopy for Determination of API Particles in a Formulated Tablet

Table 1

List of used APIs, excipients, their melting points, and composition of mixture and tablets.

	Tadalafil	Meloxicam	Calcium carbonate	Methocel	Lactose monohydrate	Avicel PH102	Colloidal silicon dioxide	Crospovidone	Magnesium stearate	Povidone
Melting point [°C]	286–295	242–250	825	225–230	214–216	260–275	1600	150–180	117–150	150–180
Mixture 1	●			●
TFL Tbl 1	●		●		●		●		●
ME Tbl 1		●			●	●	●	●	●
ME Tbl 2		●			●	●	●	●	●	●