Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 832736, 9 pages
http://dx.doi.org/10.1155/2014/832736
Research Article

Generation of Insulin-Producing Cells from Human Bone Marrow-Derived Mesenchymal Stem Cells: Comparison of Three Differentiation Protocols

1Department of Biotechnology, Urology and Nephrology Center, Mansoura 35516, Egypt
2Department of Nephrology, Urology and Nephrology Center, Mansoura 35516, Egypt
3Department of Pathology, Urology and Nephrology Center, Mansoura 35516, Egypt
4Department of Immunology, Urology and Nephrology Center, Mansoura 35516, Egypt
5Zewail University of Science and Technology, 6th of October City, Giza 12588, Egypt
6Department of Urology, Urology and Nephrology Center, Mansoura 35516, Egypt

Received 9 January 2014; Revised 3 March 2014; Accepted 12 March 2014; Published 10 April 2014

Academic Editor: Aijun Wang

Copyright © 2014 Mahmoud M. Gabr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Tables 1, 2, and 3 provide the numerical values of relative gene expression of HBM-MSCs obtained from the 3 donors: at the end of expansion as well as at the end of differentiation. The tables also provide a comparison between the 3 studied differentiation protocols; values of human islets are used for reference.

Values of in vitro released human insulin (table 4) and c-peptide (table 5) as a function of a glucose challenge by the differentiated HBM-MSCs obtained from the three donors with a comparison between the 3 studied differentiation protocols.

  1. Supplementary Tables