BioMed Research International / 2014 / Article / Tab 1

Review Article

New Insights in the Mobilization of Hematopoietic Stem Cells in Lymphoma and Multiple Myeloma Patients

Table 1

Receptors, ligands, and adhesions molecules involved in the homeostasis of the HSC niche.

Expression from HSCExpression from BM stroma

Tie2 Ang-1
Mpl TPO
c-kit (CD117)SCF
CXCR4SDF-1 (CXCL12)
TGF-R TGF-
FGFR1-4FGF
NotchJagged-1
GRP78Cripto
PTH-R
HIF-1Cripto
N-cadherinN-cadherin
BMP-R2ABMP
VLA4VCAM-1
FrizzledWnt (ECM)
FLT-3 (CD135)FLT3 ligand
CaRCa++ (ECM)
HCAM (CD44)Hyaluronan (ECM)
LFA-1ICAM-1
VEGFVEGFR
Agrin-RAgrin proteoglycan (ECM)
S1P1S1P

Ang-1: angiopoietin-1, SCF: stem cell factor, SDF-1: stromal-derived factor-1, FGF: fibroblast growth factor, PTH-R: parathormone receptor, Cripto: teratocarcinoma derived growth factor-1/TDGF-1, BMP: bone morphogenic protein, VLA4: very late antigen 4, VCAM-1: vascular cellular adhesion molecule-1, FLT-3: fms-like tyrosine kinase 3, HCAM: hyaluronan binding-cellular adhesion molecule, LFA-1: lymphocyte function-associated antigen-1, VEGF: vascular endothelial growth factor, S1P: sphingosine-1-phosphate, and ECM: extracellular matrix.