Targeting the Raft-Associated Akt Signaling in Hepatocellular Carcinoma
Figure 2
Upregulation of caveolin-1 and flotillin-1 in HCC tissues. (a) Caveolae and planar lipid raft are specialized plasma membrane microdomains that are enriched in cholesterol and sphingolipids and are involved in fundamental cellular events such as signal transduction, cell adhesion, lipid/protein sorting, and human cancer. Caveolin-1 and flotillin-1 are considered as markers of caveolae and planar lipid raft which can recruit signaling molecules into lipid rafts. (b) Representative images from immunohistochemistry analyses of caveolin-1 and flotillin-1 expression in HCC tissues (T) and matched adjacent noncancerous tissues (ANT) and HCC specimens of different histologic grades.
