Figure 5: Akt signaling pathway components involved in the regulation of cell survival are altered in lipid rafts of HCC patients. (a) There are no significant changes in the Akt concentration or its phosphorylation state in the plasma membrane of HCC and ANT tissues. (b) The amount of Akt phosphorylation in the lipid rafts significantly increased in HCC compared to ANT tissues. (c) The level of mTOR significantly increased but, respectively, decreased in phosphorylation of BAD in the lipid rafts of HCC tissues. , ∗∗, and ∗∗∗ compared with the ANT, t-test ( independent experiments).