Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor
Characterization of BM-MSCs and HUCPVCs. (a) Flow cytometry analysis of cell surface markers of both types of MSCs. Grey area indicates background fluorescence with IgG isotype control. One representative experiment is shown. (b) In vitro migration of BM-MSCs (black bars) or HUCPVCs (grey bars) towards CCM from HCC (HuH7 and HC-PT-5), hepatic stellate cells (LX-2), fibroblasts (WI-38), or endothelial cells (HMEC-1). Bars represent the average of MSCs/field (10x) ± SEM from three representative visual fields. Results are representative of 3 independent experiments. versus DMEM; versus BM-MSCs. (c) Adhesion towards endothelial cells of BM-MSCs (black bars) or HUCPVCs (grey bars). Results are representative of 3 independent experiments. versus BM-MSCs.
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