Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 839538, 8 pages
http://dx.doi.org/10.1155/2014/839538
Research Article

Impact Assessment of Cadmium Toxicity and Its Bioavailability in Human Cell Lines (Caco-2 and HL-7702)

1Ministry of Education Key, Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China
2Department of Environmental Sciences, International Islamic University, Islamabad 44000, Pakistan
3College of Architecture and Environment, Sichuan University, Chengdu 610065, China
4Indian River Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Fort Pierce, FL 34945, USA
5Department of Biotechnology & Genetic Engineering, Kohat University of Science and Technology, Kohat 26000, Pakistan

Received 21 August 2013; Revised 23 October 2013; Accepted 9 November 2013; Published 16 February 2014

Academic Editor: Qaisar Mahmood

Copyright © 2014 Rukhsanda Aziz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. K. Daud, S. Ali, M. T. Variath et al., “Differential physiological, ultra-morphological and metabolic responses of cotton cultivars under cadmium stress,” Chemosphere, vol. 93, no. 10, pp. 2593–2602, 2013. View at Publisher · View at Google Scholar
  2. G. C. Lalor, “Review of cadmium transfers from soil to humans and its health effects and Jamaican environment,” Science of the Total Environment, vol. 400, no. 1–3, pp. 162–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. K. Daud, Y. Sun, M. Dawood et al., “Cadmium-induced functional and ultrastructural alterations in roots of two transgenic cotton cultivars,” Journal of Hazardous Materials, vol. 161, no. 1, pp. 463–473, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. C. Merrill, J. J. P. Morton, and S. D. Soileau, “Metals: cadmium,” in Principles and Methods of Toxicology, A. W. Hayes, Ed., pp. 665–667, Taylor and Francis, London, UK, 2001. View at Google Scholar
  5. M. K. Daud, M. T. Variath, S. Ali et al., “Cadmium-induced ultramorphological and physiological changes in leaves of two transgenic cotton cultivars and their wild relative,” Journal of Hazardous Materials, vol. 168, no. 2-3, pp. 614–625, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. P. N. Williams, M. Lei, G. Sun et al., “Occurrence and partitioning of cadmium, arsenic and lead in mine impacted paddy rice: Hunan, China,” Environmental Science and Technology, vol. 43, no. 3, pp. 637–642, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. U. Khan, R. N. Malik, and S. Muhammad, “Human health risk from heavy metal via food crops consumption with wastewater irrigation practices in Pakistan,” Chemosphere, vol. 93, no. 10, pp. 2230–2238, 2013. View at Google Scholar
  8. O. Andersen, J. B. Nielsen, J. A. Sorensen, and L. Scherrebeck, “Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice,” Environmental Health Perspectives, vol. 102, no. 3, pp. 199–206, 1994. View at Google Scholar · View at Scopus
  9. R. K. Zalups and S. Ahmad, “Molecular handling of cadmium in transporting epithelia,” Toxicology and Applied Pharmacology, vol. 186, no. 3, pp. 163–188, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Elsenhans, G. J. Strugala, and S. G. Schäfer, “Small-intestinal absorption of cadmium and the significance of mucosal metallothionein,” Human and Experimental Toxicology, vol. 16, no. 8, pp. 429–434, 1997. View at Google Scholar · View at Scopus
  11. R. Arriazu, J. M. Pozuelo, N. Henriques-Gil et al., “Immunohistochemical study of cell proliferation, Bcl-2, p53, and caspase-3 expression on preneoplastic changes induced by cadmium and zinc chloride in the ventral rat prostate,” Journal of Histochemistry and Cytochemistry, vol. 54, no. 9, pp. 981–990, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Huang, Y. Zhang, Y. Qi, C. Chen, and W. Ji, “Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of cadmium-stimulated K562 cell proliferation,” Toxicology Letters, vol. 179, no. 1, pp. 43–47, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Yang, H. Chen, J. Tsai, and L. Lin, “Cadmium induces Ca2+-dependent necrotic cell death through calpain-triggered mitochondrial depolarization and reactive oxygen species-mediated inhibition of nuclear factor-κB activity,” Chemical Research in Toxicology, vol. 20, no. 3, pp. 406–415, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Shih, W. Ko, J. Wu et al., “Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts,” Journal of Cellular Biochemistry, vol. 91, no. 2, pp. 384–397, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Fotakis and J. A. Timbrell, “Role of trace elements in cadmium chloride uptake in hepatoma cell lines,” Toxicology Letters, vol. 164, no. 2, pp. 97–103, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. V. Berridge and A. S. Tan, “Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction,” Archives of Biochemistry and Biophysics, vol. 303, no. 2, pp. 474–482, 1993. View at Publisher · View at Google Scholar · View at Scopus
  17. M. R. Ruocco, F. Cecere, A. Iuliano et al., “Diclofenac-induced apoptosis in the neuroblastoma cell line SH-SY5Y: possible involvement of the mitochondrial superoxide dismutase,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 801726, 11 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. S. S. Baker and R. D. Baker, “Antioxidant enzymes in the differentiated Caco-2 cell line,” In Vitro Cellular and Developmental Biology, vol. 28, no. 9-10, pp. 643–647, 1992. View at Google Scholar · View at Scopus
  19. S. Chater, T. Douki, A. Favier, M. Sakly, and H. Abdelmelek, “Changes in antioxidant status and biochemical parameters after orally cadmium administration in females rats,” Acta Biologica Hungarica, vol. 60, no. 1, pp. 79–88, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Nzengue, R. Steiman, C. Garrel, E. Lefèbvre, and P. Guiraud, “Oxidative stress and DNA damage induced by cadmium in the human keratinocyte HaCaT cell line: role of glutathione in the resistance to cadmium,” Toxicology, vol. 243, no. 1-2, pp. 193–206, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Wang, J. Fang, S. S. Leonard, and K. M. K. Rao, “Cadmium inhibits the electron transfer chain and induces reactive oxygen species,” Free Radical Biology and Medicine, vol. 36, no. 11, pp. 1434–1443, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. V. Meunier, M. Bourrie, Y. Berger, and G. Fabre, “The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications,” Cell Biology and Toxicology, vol. 11, no. 3-4, pp. 187–194, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. Xie, Y. Zhang, A. Li, P. Li, W. Ji, and D. Huang, “Cd-induced apoptosis was mediated by the release of Ca2+ from intracellular Ca storage,” Toxicology Letters, vol. 192, no. 2, pp. 115–118, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Jumarie, P. G. C. Campbell, A. Berteloot, M. Houde, and F. Denizeau, “Caco-2 cell line used as an in vitro model to study cadmium accumulation in intestinal epithelial cells,” Journal of Membrane Biology, vol. 158, no. 1, pp. 31–48, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Google Scholar · View at Scopus
  26. B. Zödl, M. Zeiner, M. Sargazi et al., “Toxic and biochemical effects of zinc in Caco-2 cells,” Journal of Inorganic Biochemistry, vol. 97, no. 4, pp. 324–330, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. D. M. Templeton, “Biomedical aspects of trace element speciation,” Fresenius' Journal of Analytical Chemistry, vol. 363, no. 5-6, pp. 505–511, 1999. View at Google Scholar · View at Scopus
  28. Y. Ui-Jeong, Y. So-Ra, C. Jae-Hwan et al., “Water spinach (Ipomoea aquatic Forsk.) reduced the absorption of heavy metals in an in vitro bio-mimicking model system,” Food and Chemical Toxicology, vol. 50, pp. 3862–3866, 2012. View at Google Scholar
  29. D. A. Vesey, “Transport pathways for cadmium in the intestine and kidney proximal tubule: focus on the interaction with essential metals,” Toxicology Letters, vol. 198, no. 1, pp. 13–19, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. E. C. Foulkes, “Transport of toxic heavy metals across cell membranes,” Proceedings of the Society for Experimental Biology and Medicine, vol. 223, no. 3, pp. 234–240, 2000. View at Google Scholar · View at Scopus
  31. N. J. DelRaso, B. D. Foy, J. M. Gearhart, and J. M. Frazier, “Cadmium uptake kinetics in rat hepatocytes: correction for albumin binding,” Toxicological Sciences, vol. 72, no. 1, pp. 19–30, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. E. A. Belyaeva, V. V. Glazunov, and S. M. Korotkov, “Cyclosporin A-sensitive permeability transition pore is involved in Cd2+-induced dysfunction of isolated rat liver mitochondria: doubts no more,” Archives of Biochemistry and Biophysics, vol. 405, no. 2, pp. 252–264, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Pourahmad and P. J. O'Brien, “A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+,” Toxicology, vol. 143, no. 3, pp. 263–273, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Nemmiche, D. Chabane-Sari, M. Kadri, and P. Guiraud, “Cadmium chloride-induced oxidative stress and DNA damage in the human Jurkat T cell line is not linked to intracellular trace elements depletion,” Toxicology in Vitro, vol. 25, no. 1, pp. 191–198, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Bagchi, M. Bagchi, S. J. Stohs et al., “Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention,” Toxicology, vol. 148, no. 2-3, pp. 187–197, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. J. M. Matés, “Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology,” Toxicology, vol. 153, no. 1–3, pp. 83–104, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Waisberg, P. Joseph, B. Hale, and D. Beyersmann, “Molecular and cellular mechanisms of cadmium carcinogenesis,” Toxicology, vol. 192, no. 2-3, pp. 95–117, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. U. R. Acharya, M. Mishra, J. Patro, and M. K. Pan, “Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium,” Reproductive Toxicology, vol. 25, no. 1, pp. 84–88, 2008. View at Google Scholar · View at Scopus
  39. F. M. Maiorino, R. Brigelius-Flohé, K. D. Aumann, A. Roveri, D. Schomburg, and L. Flohé, “Diversity of glutathione peroxidases,” Methods in Enzymology, vol. 252, pp. 38–53, 1995. View at Google Scholar · View at Scopus
  40. S. V. Rana, S. Rekha, and V. Seema, “Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury,” Indian Journal of Experimental Biology, vol. 34, no. 2, pp. 177–179, 1996. View at Google Scholar · View at Scopus
  41. F. M. El-Demerdash, M. I. Yousef, F. S. Kedwany, and H. H. Baghdadi, “Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene,” Food and Chemical Toxicology, vol. 42, no. 10, pp. 1563–1571, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. F. M. El-Demerdash and E. I. Elagamy, “Biological effects in Tilapia nilotica fish as indicators of pollution by cadmium and mercury,” International Journal of Environmental Health Research, vol. 9, no. 3, pp. 143–156, 1999. View at Google Scholar
  43. F. M. El-Demerdash, M. I. Yousef, and E. I. Elagamy, “Influence of paraquat, glyphosate, and cadmium on the activity of some serum enzymes and protein electrophoretic behavior (in vitro),” Journal of Environmental Science and Health B, vol. 36, no. 1, pp. 29–42, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. R. Lakshmi, R. Kundu, E. Thomas, and A. P. Mansuri, “Mercuric chloride induced inhibition of acid and alkaline phosphatase activity in the kidney of Mudskipper, Boleophthalmus dentatus,” Acta Hydrochimica et Hydrobiologica, vol. 3, pp. 341–344, 1991. View at Google Scholar