Adenosine Amine Congener as a Cochlear Rescue Agent

Figure 1

ADAC dose-response study in Wistar rats: the effect on auditory brainstem responses (ABR) before (blue line) and 12 days after (red line) traumatic noise exposure (8–16 kHz, 110 dB SPL, 2 hours). ADAC (25–300 μg/kg) was administered intraperitoneally for five consecutive days at 24 h intervals, commencing six hours after noise exposure. In the control group, injections of the vehicle solution were administered at the same intervals as ADAC. ABR were measured in response to tone pips (8–28 kHz). Data are expressed as mean ± SEM (–10).