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BioMed Research International
Volume 2014, Article ID 841497, 7 pages
Research Article

Risks of Decreased Renal Function and Increased Albuminuria for Glycemic Status and Metabolic Syndrome Components: Taichung Community Health Study

1Department of Family Medicine, China Medical University Hospital, Taichung 40402, Taiwan
2School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan
3Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan
4Medical College, Department of Psychiatry, Medical College, National Cheng Kung University, Tainan 70101, Taiwan
5Bristol-Myers Squibb Ltd, Global Development & Medical Affair, Taipei 10586, Taiwan
6Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung 40402, Taiwan
7Graduate Institute of Biostatistics, College of Management, China Medical University, Taichung 40402, Taiwan
8Department of Healthcare Administration, College of Health Science, Asia University, Taichung 41354, Taiwan

Received 10 January 2014; Revised 16 April 2014; Accepted 21 April 2014; Published 12 May 2014

Academic Editor: Abel Romero-Corral

Copyright © 2014 Cheng-Chieh Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The objective of this study was to assess the association of glycemic status and decreased renal function as determined by estimated glomerular filtration rate (eGFR) and albuminuria in an adult Taiwanese metropolitan population. Methods. We did a cross-sectional survey in a representative sample of 2,350 Taiwanese adults aged 40 years and over living in a metropolitan city in Taiwan from 2004 to 2005. Glycemic status was classified as normal glycemia, hyperglycemia, and type 2 diabetes (T2D). Renal function was assessed with eGFR using modified Modification of Diet in Renal Disease Study equation for Chinese. Albuminuria was determined by the urinary albumin-creatinine ratio. Decreased renal function was defined as eGFR <60 mL/min/1.73 m2 and albuminuria as the albumin-creatinine ratio >30 mg g−1 creatinine. Results. 593 (25.23%) had hyperglycemia and 287 (12.21%) had T2D. As glycemia level increased, the prevalence of albuminuria and decreased eGFR increased. After adjustment, T2D was associated with an OR of 2.93 (95% CI: 2.11–4.07) for albuminuria, and an OR of 2.05 (95% CI: 1.18–3.58) for decreased eGFR. Conclusions. In a representative sample from a metropolitan city in Taiwan, T2D was associated with albuminuria and decreased eGFR.