Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair

Table 1

Cell	Proteoglycan	CNS; specific	Location	Inhibitory to axonal growth	References
Neurons	Aggrecan	No	ECM	YES	[166, 167]
	Brevican	Yes	ECM	YES	[22, 105]
	Neurocan	Yes	ECM	YES	[16, 22, 105, 168, 169]
	Phosphacan	Yes	ECM	YES	[16, 22, 105, 168, 169]
Astrocytes	Brevican	Yes	ECM	YES	[22, 105, 116]
	Neurocan	Yes	ECM	YES	[16, 22, 105, 116, 168, 169]
	Phosphacan	Yes	ECM	YES	[16, 22, 105, 116, 121, 122, 168, 169]
Activated; microglial cells	KSPGs	No	TM & ECM	YES	[92, 93, 170]
	NG2	No	TM & ECM	?	[92, 108, 109, 121, 122, 171–174]
Oligodendrocyte progenitor cells	KSPGs	No	TM & ECM	YES	[92, 93, 170]
	NG2	No	TM & ECM	?	[92, 108, 109, 121, 122, 171]
	Versican (V2)	Yes	ECM	NO?	[106, 108]
Polydendrocytes	NG2	No	TM & ECM	?	[92, 108, 109, 121, 122]
Activated vascular macrophages	KSPGs	No	TM & ECM	YES	[92, 93, 170]
	NG2	No	TM & ECM	?	[92, 108, 109, 121, 122, 173, 174]

Abbreviations: TM: transmembrane; ECM: extracellular matrix.