Formulation and Evaluation of Thermosensitive Biogels for Nose to Brain Delivery of Doxepin

Table 2

Histopathological study of nasal tissue in mice.

Characteristic features	C-GP-DOX	C-GP-PEG-Dox	Dox solution
Glandular hyperplasia	Mild	Mild	Mild
Infiltration of the inflammatory cells	Mild	Mild	Mild
Epithelial hyperplasia	Mild	Moderate	Mild
Sluffing of mucosal epithelium	—	—	Mild
Congestion	—	—	—