BioMed Research International
Volume 2014 (2014), Article ID 848604, 13 pages
http://dx.doi.org/10.1155/2014/848604
Research Article
Development and Retranslational Validation of an In Vitro Model to Characterize Acute Infections in Large Human Joints
Department of Orthopedic Surgery, University of Freiburg Medical Center, Hugstetter Straße 55, 79106 Freiburg, Germany
Received 3 September 2013; Accepted 9 April 2014; Published 30 April 2014
Academic Editor: Shigeru Kotake
Copyright © 2014 Ingo H. Pilz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- J. S. Pober and W. C. Sessa, “Evolving functions of endothelial cells in inflammation,” Nature Reviews Immunology, vol. 7, no. 10, pp. 803–815, 2007. View at Publisher · View at Google Scholar · View at Scopus
- H.-G. Simank, B. Wadi, and L. Bernd, “Joint empyema,” Der Orthopade, vol. 33, no. 3, pp. 327–331, 2004. View at Publisher · View at Google Scholar · View at Scopus
- M. Diefenbeck, D. Abitzsch, and G. O. Hofmann, “Joint infections. Known facts and new trends,” Der Unfallchirurg, vol. 115, no. 6, pp. 489–495, 2012. View at Google Scholar
- J. A. Buckwalter, “Articular cartilage: injuries and potential for healing,” The Journal of Orthopaedic and Sports Physical Therapy, vol. 28, no. 4, pp. 192–202, 1998. View at Google Scholar · View at Scopus
- J. A. Buckwalter and J. Martin, “Degenerative joint disease,” Clinical symposia, vol. 47, no. 2, pp. 1–32, 1995. View at Google Scholar · View at Scopus
- E. B. Hunziker, “Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects,” Osteoarthritis and Cartilage, vol. 10, no. 6, pp. 432–463, 2002. View at Publisher · View at Google Scholar · View at Scopus
- K. P. Gunther, H. P. Scharf, and W. Puhl, “Standardization of roentgen diagnosis in coxarthrosis and gonarthrosis in clinical studies. Recommendations of the 1st Working Circle of the DGOT (Connective Tissue Research and Arthrosis Deformans),” Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete, vol. 135, no. 3, pp. 193–196, 1997. View at Google Scholar
- P. Riegels-Nielsen, N. Frimodt-Moller, and J. S. Jensen, “Rabbit model of septic arthritis,” Acta Orthopaedica Scandinavica, vol. 58, no. 1, pp. 14–19, 1987. View at Google Scholar · View at Scopus
- Y. Shimizu and S. Shaw, “Lymphocyte interactions with extracellular matrix,” The FASEB Journal, vol. 5, no. 9, pp. 2292–2299, 1991. View at Google Scholar · View at Scopus
- C. Nathan and M. Sporn, “Cytokines in context,” The Journal of Cell Biology, vol. 113, no. 5, pp. 981–986, 1991. View at Google Scholar · View at Scopus
- A. D. Pearle, R. F. Warren, and S. A. Rodeo, “Basic science of articular cartilage and osteoarthritis,” Clinics in Sports Medicine, vol. 24, no. 1, pp. 1–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
- K. Bobacz, L. Erlacher, J. Smolen, A. Soleiman, and W. B. Graninger, “Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage,” Annals of the Rheumatic Diseases, vol. 63, no. 12, pp. 1618–1622, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. Jerosch, “Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially omega-3 fatty acids,” International Journal of Rheumatology, vol. 2011, Article ID 969012, 17 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Schmal, I. H. Pilz, A. T. Mehlhorn et al., “Expression of BMP-receptor type 1A correlates with progress of osteoarthritis in human knee joints with focal cartilage lesions,” Cytotherapy, vol. 14, no. 7, pp. 868–876, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. M. van Buul, G. Kotek, P. A. Wielopolski et al., “Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides,” PLoS ONE, vol. 6, no. 2, Article ID e17001, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. B. Goldring, J. Birkhead, L. J. Sandell, T. Kimura, and S. M. Krane, “Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes,” The Journal of Clinical Investigation, vol. 82, no. 6, pp. 2026–2037, 1988. View at Google Scholar · View at Scopus
- E. B. Hunziker, “Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?” Osteoarthritis and Cartilage, vol. 7, no. 1, pp. 15–28, 1999. View at Publisher · View at Google Scholar · View at Scopus
- E. T. Rietschel, T. Kirikae, F. U. Schade et al., “Bacterial endotoxin: molecular relationships of structure to activity and function,” The FASEB Journal, vol. 8, no. 2, pp. 217–225, 1994. View at Google Scholar
- M. J. Auger, “Mononuclear phagocytes. Recent research suggests a large repertoire of actions,” British Medical Journal, vol. 298, no. 6673, pp. 546–548, 1989. View at Google Scholar · View at Scopus
- N. V. Serbina, T. Jia, T. M. Hohl, and E. G. Pamer, “Monocyte-mediated defense against microbial pathogens,” Annual Review of Immunology, vol. 26, pp. 421–452, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Fenton, M. W. Vermeulen, B. D. Clark, A. C. Webb, and P. E. Auron, “Human pro-IL-1β gene expression in monocytic cells is regulated by two distinct pathways,” Journal of Immunology, vol. 140, no. 7, pp. 2267–2273, 1988. View at Google Scholar · View at Scopus
- J. L. Lepe-Zuniga and I. Gery, “Production of intra- and extracellular interleukin-1 (IL-1) by human monocytes,” Clinical Immunology and Immunopathology, vol. 31, no. 2, pp. 222–230, 1984. View at Google Scholar · View at Scopus
- H. Schmal, A. Mehlhorn, F. Stoffel, W. Kstler, N. P. Sdkamp, and P. Niemeyer, “In vivo quantification of intraarticular cytokines in knees during natural and surgically induced cartilage repair,” Cytotherapy, vol. 11, no. 8, pp. 1065–1075, 2009. View at Publisher · View at Google Scholar · View at Scopus
- C. B. Knudson and W. Knudson, “Cartilage proteoglycans,” Seminars in Cell and Developmental Biology, vol. 12, no. 2, pp. 69–78, 2001. View at Publisher · View at Google Scholar · View at Scopus
- K. J. Doege, M. Sasaki, T. Kimura, and Y. Yamada, “Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms,” The Journal of Biological Chemistry, vol. 266, no. 2, pp. 894–902, 1991. View at Google Scholar · View at Scopus
- L. S. Lohmander, M. Ionescu, H. Jugessur, and A. R. Poole, “Changes in joint cartilage aggrecan after knee injury and in osteoarthritis,” Arthritis and Rheumatism, vol. 42, no. 3, pp. 534–544, 1999. View at Google Scholar
- T. Vincent, M. Hermansson, M. Bolton, R. Wait, and J. Saklatvala, “Basic FGF mediates an immediate response of articular cartilage to mechanical injury,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 12, pp. 8259–8264, 2002. View at Publisher · View at Google Scholar · View at Scopus
- R. L. Sah, A. C. Chen, A. J. Grodzinsky, and S. B. Trippel, “Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants,” Archives of Biochemistry and Biophysics, vol. 308, no. 1, pp. 137–147, 1994. View at Publisher · View at Google Scholar · View at Scopus
- S. Chubinskaya, M. Hurtig, and D. C. Rueger, “OP-1/BMP-7 in cartilage repair,” International Orthopaedics, vol. 31, no. 6, pp. 773–781, 2007. View at Publisher · View at Google Scholar · View at Scopus
- M. Hurtig, S. Chubinskaya, J. Dickey, and D. Rueger, “BMP-7 protects against progression of cartilage degeneration after impact injury,” Journal of Orthopaedic Research, vol. 27, no. 5, pp. 602–611, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. H. Marks and M. L. C. Donaldson, “Inflammatory cytokine profiles associated with chondral damage in the anterior cruciate ligament-deficient knee,” Arthroscopy: The Journal of Arthroscopic and Related Surgery, vol. 21, no. 11, pp. 1342–1347, 2005. View at Publisher · View at Google Scholar · View at Scopus
- F. M. Brennan, A. L. Hayes, C. J. Ciesielski, P. Green, B. M. Foxwell, and M. Feldmann, “Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 46, no. 1, pp. 31–41, 2002. View at Google Scholar
- H. Schmal, A. T. Mehlhorn, J. Zwingmann, C. A. Müller, G. B. Stark, and N. P. Südkamp, “Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF),” Cytotherapy, vol. 7, no. 3, pp. 292–300, 2005. View at Publisher · View at Google Scholar · View at Scopus
- D. J. McQuillan, C. J. Handley, and M. A. Campbell, “Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage,” Biochemical Journal, vol. 240, no. 2, pp. 423–430, 1986. View at Google Scholar · View at Scopus
- J. Middleton, A. Manthey, and J. Tyler, “Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1β (IL- 1β), and IL-6 mRNA expression in osteoarthritic and normal human cartilage,” The Journal of Histochemistry and Cytochemistry, vol. 44, no. 2, pp. 133–141, 1996. View at Google Scholar · View at Scopus
- J. A. Tyler, “Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines,” The Biochemical Journal, vol. 260, no. 2, pp. 543–548, 1989. View at Google Scholar · View at Scopus
- S. Chubinskaya, D. Segalite, D. Pikovsky, A. A. Hakimiyan, and D. C. Rueger, “Effects induced by BMPS in cultures of human articular chondrocytes: comparative studies,” Growth Factors, vol. 26, no. 5, pp. 275–283, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. D. Huebner, N. G. Shrive, and C. B. Frank, “New surgical model of post-traumatic osteoarthritis: isolated intra-articular bone injury in the rabbit,” Journal of Orthopaedic Research, vol. 31, no. 6, pp. 914–920, 2013. View at Publisher · View at Google Scholar
- K. E. Kuettner and A. A. Cole, “Cartilage degeneration in different human joints,” Osteoarthritis and Cartilage, vol. 13, no. 2, pp. 93–103, 2005. View at Publisher · View at Google Scholar · View at Scopus
- I. B. Mcinnes, B. P. Leung, R. D. Sturrock, M. Field, and F. Y. Liew, “Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis,” Nature Medicine, vol. 3, no. 2, pp. 189–195, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. B. Goldring, “Osteoarthritis and cartilage: the role of cytokines,” Current Rheumatology Reports, vol. 2, no. 6, pp. 459–465, 2000. View at Google Scholar · View at Scopus
- S. Lefèvre, A. Knedla, C. Tennie et al., “Synovial fibroblasts spread rheumatoid arthritis to unaffected joints,” Nature Medicine, vol. 15, no. 12, pp. 1414–1420, 2009. View at Publisher · View at Google Scholar · View at Scopus
- H.-J. Im, P. Muddasani, V. Natarajan et al., “Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cδ pathways in human adult articular chondrocytes,” Journal of Biological Chemistry, vol. 282, no. 15, pp. 11110–11121, 2007. View at Publisher · View at Google Scholar · View at Scopus
- H. Schmal, J. Zwingmann, M. Fehrenbach et al., “bFGF influences human articular chondrocyte differentiation,” Cytotherapy, vol. 9, no. 2, pp. 184–193, 2007. View at Publisher · View at Google Scholar · View at Scopus
- E. W. Mandl, H. Jahr, J. L. M. Koevoet et al., “Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture,” Matrix Biology, vol. 23, no. 4, pp. 231–241, 2004. View at Publisher · View at Google Scholar · View at Scopus
- K. Huch, “Long-term effects of osteogenic protein-1 on biosynthesis and proliferation of human articular chondrocytes,” Clinical and Experimental Rheumatology, vol. 19, no. 5, pp. 525–531, 2001. View at Google Scholar · View at Scopus
- K. Bobacz, I. G. Sunk, J. G. Hofstaetter et al., “Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7,” Arthritis and Rheumatism, vol. 56, no. 6, pp. 1880–1893, 2007. View at Publisher · View at Google Scholar · View at Scopus
- T. Takahashi, T. Muneta, K. Tsuji, and I. Sekiya, “BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis,” Cell and Tissue Research, vol. 344, no. 2, pp. 321–332, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Honsawek, M. Chayanupatkul, A. Tanavalee et al., “Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study,” International Orthopaedics, vol. 33, no. 4, pp. 1171–1175, 2009. View at Publisher · View at Google Scholar · View at Scopus