Research Article
High Expression of Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Predicts Poor Prognosis in Head and Neck Squamous Cell Carcinoma
Table 2
Correlations between LETM1 protein overexpression and clinicopathological features of HNSCC patients.
| Clinical features | Number of cases () | LETM1 strongly positive cases (%) | | value |
| Gender | | | | | Male | 113 | 72 (63.7%) | 0.368 | 0.545 | Female | 63 | 43 (68.3%) | | | Age (years) | | | | | ≤60 | 106 | 67 (63.2%) | 0.536 | 0.466 | >60 | 70 | 48 (68.6%) | | | Primary site | | | | | Tongue | 92 | 56 (60.9%) | 4.133 | 0.764 | Buccal | 37 | 29 (78.4%) | | | Gingiva | 28 | 19 (67.9%) | | | Floor of mouth | 19 | 11 (57.9%) | | | Tumor differentiation | | | | | Well | 59 | 33 (55.9%) | 5.988 | 0.016* | Moderately | 81 | 53 (65.4%) | | | Poorly | 36 | 29 (80.6%) | | | pT | | | | | T1-2 | 72 | 42 (58.3%) | 0.93 | 0.334 | T3-4 | 104 | 53 (50.9%) | | | Lymph node | | | | | N0 | 43 | 19 (44.2%) | 11.245 | 0.001** | N+ | 133 | 96 (72.2%) | | | Tumor stage | | | | | I-II | 53 | 19 (35.8%) | 29.13 | 0.001** | III-IV | 123 | 96 (78.0%) | | | Alcohol use | | | | | Positive | 113 | 78 (69.0%) | 1.89 | 0.168 | Negative | 63 | 37 (58.7%) | | | Smoking status | | | | | Current/former | 104 | 71 (76.0%) | 0.963 | 0.328 | Never | 72 | 44 (50.0%) | | | Chemoradiotherapy | | | | | Yes | 117 | 67 (57.3%) | 10.052 | 0.002** | No | 59 | 48 (81.4%) | | |
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