An In Vivo Microdialysis Study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats
Figure 4
Brain dialysate FLZ profiles in the different groups ( per group). (a) FLZ concentrations in brain dialysate samples collected at different times from the FLZ only-N and FLZ only-PD groups. The differences in FLZ levels between these two groups were not significant. (b) FLZ concentrations in brain dialysate samples taken at different times from the FLZ only-N and FLZ + ZOSUQ-N groups. FLZ concentrations were significantly higher in the FLZ + ZOSUQ-N group than in the FLZ only-N group (between the third and twelfth samples; the eleventh sample is the exception). (c) FLZ concentrations in brain dialysate samples taken at different times from the FLZ only-PD and FLZ + ZOSUQ-PD groups. FLZ concentrations were significantly higher in the FLZ + ZOSUQ-PD group than in the FLZ only-PD group (between the fourth and fourteenth samples). (d) FLZ concentrations in brain dialysate samples taken at different times from the FLZ + ZOSUQ-N and FLZ + ZOSUQ-PD groups. There was no statistically significant difference in FLZ levels between these two groups. ; ; . Data are expressed as the mean ± SD. Note: FLZ dialysate samples were collected from the FLZ only-N and FLZ only-PD groups for 3.5 hours (brain dialysate concentrations after this period were below the limit of quantification).
