An In Vivo Microdialysis Study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats

Table 1

Key pharmacokinetic parameters and FLZ BBB penetration values (𝑛=3 per group).

		FLZ only-N	FLZ only-PD	FLZ + ZOSUQ-N	FLZ + ZOSUQ-PD
AUC (𝜇g/L × h)	Blood	2349 ± 39	3072 ± 621	1562 ± 881	1334 ± 259*
	Brain	145 ± 25	145 ± 18	324 ± 46**	333 ± 103*
𝑡1/2 (h)	Blood	1.21 ± 0.22	1.34 ± 0.03	1.11 ± 0.13	1.43 ± 0.25
	Brain	1.15 ± 0.57	1.31 ± 0.29	1.04 ± 0.43	1.14 ± 0.27
CLz (L/h/kg)	Blood	14.9 ± 0.2	11.7 ± 2.5	28.4 ± 16.8	26.8 ± 4.7**
Ri (AUCbrain/AUCblood)		0.0617 ± 0.0105	0.0492 ± 0.0158	0.2485 ± 0.1142*	0.2459 ± 0.0270***

^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001.