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BioMed Research International
Volume 2014 (2014), Article ID 850802, 9 pages
Research Article

ECR-MAPK Regulation in Liver Early Development

1School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Collaborative Innovation Center of Processing of Agricultural Products in Hubei Province, No. 68 South Xuefu Road, Changqing Garden, Wuhan 430023, China
2Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, West No. 30 Xiaohongshan, Wuhan 430071, China
3Xinxiang Institute for Drug Control, No. 17 Jiankang Road, Xinxiang 453000, China

Received 6 June 2014; Revised 27 August 2014; Accepted 16 September 2014; Published 18 December 2014

Academic Editor: Klaus Wimmers

Copyright © 2014 Xiu-Ju Zhao and Hexian Zhuo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.