ECR-MAPK Regulation in Liver Early Development

Figure 4

ECR-MAPK-mediated early individual development network. Extracellular region and space (ECR) act as nutrition ligand and information input. Ligands interact with membrane transports and SH₂-containing/MAPK related signals and regulate cell cycle, transcription, and proteolysis, leading to short-term steroid, fatty acid biosynthesis, redox and metabolic process, and long-term collagen development and organization. G protein coupled receptors/G protein, catalytic receptors, and ECR signals converge at MAPK cascades.