Atg6/UVRAG/Vps34-Containing Lipid Kinase Complex Is Required for Receptor Downregulation through Endolysosomal Degradation and Epithelial Polarity during <i>Drosophila</i> Wing Development

<table>Impaired endocytic degradation of Wnt in Atg6 or UVRAG depleted cells. Imaginal wing discs expressing RNAi by enGal4 were immunostained against Wnt. The region of RNAi is marked by the coexpression of GFP and the borderline of the region is indicated with a dashed white line (a), (b) RNAi of Atg6 and UVRAG resulted in the accumulation of Wnt in small, numerous intracellular puncta. (c) RNAi of Atg14 did not affect Wnt localization. For genotypes, see Table S4. Scale bars represent 50 <i>μ</i>m.</table>

BioMed Research International

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Figure 8

Figure 8: Atg6/UVRAG/Vps34-Containing Lipid Kinase Complex Is Required for Receptor Downregulation through Endolysosomal Degradation and Epithelial Polarity during <i>Drosophila</i> Wing Development 

Figure 8 | Atg6/UVRAG/Vps34-Containing Lipid Kinase Complex Is Required for Receptor Downregulation through Endolysosomal Degradation and Epithelial Polarity during Drosophila Wing Development 