Accumulation of Misfolded SOD1 in Dorsal Root Ganglion Degenerating Proprioceptive Sensory Neurons of Transgenic Mice with Amyotrophic Lateral Sclerosis
Figure 3
The ultrastructural morphology of VRs ((a), (c), and (d)) and DRs (b) from end-stage mice. From a qualitative point of view, similar Wallerian-like degenerative changes could be observed in both VRs (a) and DRs (b); phagocytic cells (shaded in green), in which the nucleus is dashed in blue, appear to engulf the myelin debris (shaded in red); apparently normal myelinated axons are dashed in yellow and Schwann cell profiles are dashed in magenta. ((c)–(d)) In ventral roots it is possible to observe some regenerating axons (yellow in (c)) growing inside the ghosts of folded basal lamina profiles (green in (c)) filled with Schwann cell pedicles (magenta in (c)). Occasionally, a large growth cone (yellow in (d)) filled with organelles and surrounded by Schwann cell profiles (magenta in (d)) can be detected. Scale bars: 5 μm in (a), 2.5 μm in (b), 0.5 μm in (c), and 1 μm in (d).
