The Effect of Superparamagnetic Iron Oxide with iRGD Peptide on the Labeling of Pancreatic Cancer Cells In Vitro: A Preliminary Study
Figure 5
Prussian blue-stained and neutral red solution-counterstained panc-1 cells incubated with SPIO. (a), (b) The cells were incubated with 1 μg/mL iRGD at an iron concentration of 12.6 μg/mL ((a): 20x and (b): 40x). The cells of the control groups were incubated with SPIO without iRGD ((c): 20x and (d): 40x). Higher uptake of SPIO (blue-stained granules) with iRGD peptide compared with SPIO is clearly demonstrated (c, d). Electron microscopy of cells labeled with SPIO nanoparticles (e) and SPIO nanoparticles with iRGD peptide (f) (arrows).
