Comparison of Quasispecies Diversity of HCV between Chronic Hepatitis C and Hepatocellular Carcinoma by Ultradeep Pyrosequencing

Table 2

Eight nucleotide positions showing significantly different diversity between the patients with chronic hepatitis C (CHC) and those with hepatocellular carcinoma (HCC) caused by HCV infection.

Nucleotide position	Shannon diversity index		𝑃 value	AUC by ROC
	CHC; (mean ± SD)	HCC; (mean ± SD)
1188	0.494±0.250	0.174±0.178	0.014	0.868
1200	0.504±0.245	0.176±0.200	0.014	0.88
1205	0.477±0.212	0.186±0.183	0.012	0.87
1213	0.392±0.188	0.135±0.167	0.017	0.871
1320	0.131±0.058	0.048±0.024	<0.001	0.936
1324	0.117±0.041	0.056±0.035	0.003	0.895
1327	0.121±0.049	0.060±0.035	0.009	0.885
1344	0.098±0.042	0.044±0.028	0.008	0.885