Comparison of Quasispecies Diversity of HCV between Chronic Hepatitis C and Hepatocellular Carcinoma by Ultradeep Pyrosequencing

Table 3

Fourteen amino acid positions showing significantly different diversity between the patients with chronic hepatitis C (CHC) and those with hepatocellular carcinoma (HCC) caused by HCV infection.

Amino acid position	Shannon diversity index		𝑃 value	AUC by ROC
	CHC; (mean ± SD)	HCC; (mean ± SD)
282	0.669±0.403	0.220±0.292	0.043	0.866
283	0.716±0.419	0.247±0.299	0.038	0.856
285	0.734±0.415	0.251±0.293	0.021	0.87
287	0.726±0.375	0.264±0.287	0.013	0.878
288	0.656±0.377	0.234±0.281	0.046	0.843
290	0.676±0.356	0.225±0.294	0.013	0.878
291	0.706±0.377	0.254±0.292	0.02	0.88
292	0.605±0.313	0.224±0.260	0.025	0.865
293	0.548±0.286	0.220±0.217	0.036	0.858
331	0.170±0.067	0.081±0.045	0.002	0.888
332	0.334±0.194	0.116±0.110	0.015	0.88
338	0.147±0.062	0.076±0.040	0.019	0.863
339	0.157±0.061	0.081±0.039	0.005	0.873
341	0.132±0.060	0.068±0.036	0.044	0.834