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Retracted

This article has been retracted as Figures 3(a) and 3(b) in this article are identical to Figures 2(a) and 2(b) in the published article by Chang-qiang Tan, Xia Gao, Wen-jun Cai, Xiao-yun Qian, Ling Lu, and He Huang, “Experimental Study of Local Inner Ear Gene Therapy for Controlling Autoimmune Sensorineural Hearing Loss,” BioMed Research International, vol. 2014, Article ID 134658, 10 pages, 2014. doi: 10.1155/2014/134658, but they represent different experiments.

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References

  1. C.-Q. Tan, X. Gao, L. Guo, and H. Huang, “Exogenous IL-4-expressing bone marrow mesenchymal stem cells for the treatment of autoimmune sensorineural hearing loss in a guinea pig model,” BioMed Research International, vol. 2014, Article ID 856019, 10 pages, 2014.
BioMed Research International
Volume 2014, Article ID 856019, 10 pages
http://dx.doi.org/10.1155/2014/856019
Research Article

Exogenous IL-4-Expressing Bone Marrow Mesenchymal Stem Cells for the Treatment of Autoimmune Sensorineural Hearing Loss in a Guinea Pig Model

1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No. 5 Xinmofan Road, Nanjing, Jiangsu 210009, China
2Department of Otolaryngology-Head and Neck Surgery, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China
3Department of Otolaryngology, Nanjing Stomatological Hospital, Nanjing, Jiangsu 210008, China

Received 15 January 2014; Revised 4 March 2014; Accepted 26 March 2014; Published 22 April 2014

Academic Editor: Elena Jones

Copyright © 2014 Chang-qiang Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. K. McDonough, J. R. Curtis, and K. G. Saag, “The epidemiology of glucocorticoid-associated adverse events,” Current Opinion in Rheumatology, vol. 20, no. 2, pp. 131–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Xiao, Y. Wang, L. Li et al., “Homing of chloromethylbenzoyl ammonia-labeled bone marrow mesenchymal stem cells in an immune-mediated bone marrow failure mouse model in vivo,” Genetics and Molecular Research, vol. 13, no. 1, pp. 11–21, 2014. View at Publisher · View at Google Scholar
  3. S. A. Fawzy, A. R. El-Din, E. D. Abd-El-Maksoud, and A. M. Yousry, “The possible role of mesenchymal stem cells therapy in the repair of experimentally induced colitis in male albino rats,” International Journal of Stem Cells, vol. 6, no. 2, pp. 92–103, 2013. View at Google Scholar
  4. N. Liu, J. Tian, J. Cheng, and J. Zhang, “Migration of CXCR4 gene-modified bone marrow-derived mesenchymal stem cells to the acute injured kidney,” Journal of Cellular Biochemistry, vol. 114, no. 12, pp. 2677–2689, 2013. View at Publisher · View at Google Scholar
  5. D. Yang, S. Sun, Z. Wang, P. Zhu, Z. Yang, and B. Zhang, “Stromal cell-derived factor-1 receptor CXCR4-overexpressing bone marrow mesenchymal stem cells accelerate wound healing by migrating into skin injury areas,” Cellular Reprogramming, vol. 15, no. 3, pp. 206–215, 2013. View at Google Scholar
  6. Z. Gao, P. Cheng, Y. Xue, and Y. Liu, “Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression,” Experimental and Therapeutic Medicine, vol. 4, no. 6, pp. 993–998, 2012. View at Google Scholar
  7. R. J. MacFarlane, S. M. Graham, P. S. Davies et al., “Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment,” Expert Opinion on Therapeutic Targets, vol. 17, no. 3, pp. 243–254, 2013. View at Publisher · View at Google Scholar
  8. S. J. Greco and P. Rameshwar, “Mesenchymal stem cells in drug/gene delivery: implications for cell therapy,” Therapeutic Delivery, vol. 3, no. 8, pp. 997–1004, 2012. View at Publisher · View at Google Scholar
  9. Q. Q. Chen, L. Yan, C. Z. Wang et al., “Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses,” World Journal of Gastroenterology, vol. 19, no. 29, pp. 4702–4717, 2013. View at Publisher · View at Google Scholar
  10. C. H. Ryu, K. Y. Park, Y. Hou, C. H. Jeong, S. M. Kim, and S. S. Jeun, “Gene therapy of multiple sclerosis using interferon β-secreting human bone marrow mesenchymal stem cells,” BioMed Research International, vol. 2013, Article ID 696738, 9 pages, 2013. View at Publisher · View at Google Scholar
  11. T. Yi and S. U. Song, “Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications,” Archives of Pharmacal Research, vol. 35, no. 2, pp. 213–221, 2012. View at Publisher · View at Google Scholar
  12. H. U. Scherer, M. van Pel, and R. E. M. Toes, “Mesenchymal stem cells in autoimmune diseases: hype or hope?” Arthritis Research and Therapy, vol. 12, no. 3, article 126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Geurts, O. J. Arntz, M. B. Bennink, L. A. B. Joosten, W. B. van den Berg, and F. A. J. van de Loo, “Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis,” Gene Therapy, vol. 14, no. 23, pp. 1632–1638, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Furukawa, K. Oshima, T. Tung, G. Cui, H. Laks, and L. Sen, “Overexpressed exogenous IL-4 and IL-10 paradoxically regulate allogenic T-cell and cardiac myocytes apoptosis through FAS/FASL pathway,” Transplantation, vol. 85, no. 3, pp. 437–446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. S. Gong, D. Z. Yu, and J. B. Wang, “Relationship between three inner ear antigens with different molecular weights and autoimmune inner ear disease,” Acta Oto-Laryngologica, vol. 122, no. 1, pp. 5–9, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. A. J. Friedenstein, R. K. Chailakhyan, and U. V. Gerasimov, “Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers,” Cell and Tissue Kinetics, vol. 20, no. 3, pp. 263–272, 1987. View at Google Scholar · View at Scopus
  17. G. Lisignoli, G. Remiddi, L. Cattini et al., “An elevated number of differentiated osteoblast colonies can be obtained from rat bone marrow stromal cells using a gradient isolation procedure,” Connective Tissue Research, vol. 42, no. 1, pp. 49–58, 2001. View at Google Scholar · View at Scopus
  18. B. F. McCabe, “Autoimmune sensorineural hearing loss,” Annals of Otology, Rhinology and Laryngology, vol. 88, no. 5, part 1, pp. 585–589, 1979. View at Google Scholar · View at Scopus
  19. J. R. Wang, H. W. Yuen, D. B. Shipp et al., “Cochlear implantation in patients with autoimmune inner ear disease including Cogan syndrome: a comparison with age- and sex-matched controls,” Laryngoscope, vol. 120, no. 12, pp. 2478–2483, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Maeda, K. Fukushima, S. Kariya, Y. Orita, and K. Nishizaki, “Intratympanic dexamethasone up-regulates Fkbp5 in the cochleae of mice in vivo,” Acta Oto-Laryngologica, vol. 132, no. 1, pp. 4–9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Herraiz, J. M. Aparicio, and G. Plaza, “Intratympanic drug delivery for the treatment of inner ear diseases,” Acta Otorrinolaringologica Espanola, vol. 61, no. 3, pp. 225–232, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Xenellis, N. Papadimitriou, T. Nikolopoulos et al., “Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study,” Otolaryngology—Head and Neck Surgery, vol. 134, no. 6, pp. 940–945, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. W. B. Chen, C. Q. Tan, W. D. Dong et al., “IL-10 gene imported into the inner ear for treating autoimmune sensorineural hearing loss: an experimental study,” Journal of Southeast University (Medical Science Edition), vol. 29, no. 3, pp. 262–267, 2010. View at Google Scholar
  24. T. Okano, T. Nakagawa, T. Kita, T. Endo, and J. Ito, “Cell-gene delivery of brain-derived neurotrophic factor to the mouse inner ear,” Molecular Therapy, vol. 14, no. 6, pp. 866–871, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Sharif, T. Nakagawa, T. Ohno et al., “The potential use of bone marrow stromal cells for cochlear cell therapy,” NeuroReport, vol. 18, no. 4, pp. 351–354, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. S. H. Ho, W. Hahn, H. J. Lee et al., “Protection against collagen-induced arthritis by electrotransfer of an expression plasmid for the interleukin-4,” Biochemical and Biophysical Research Communications, vol. 321, no. 4, pp. 759–766, 2004. View at Publisher · View at Google Scholar · View at Scopus