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| Maternal effect protein (gene) | Knockout mouse phenotype | Localization within oocyte | Association with maternal effect structures (MESs) |
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| Bona fide maternal effect proteins | | | |
| DNA methyltransferase (cytosine-5) 1 (Dnmt1) | Death at E14 to E21 | Cytoplasmic | Maybe CPL, MVA or SCMC |
| FILIA (2410004A20Rik) | 50% decrease in female fertility | Cortex | SCMC |
| Factor located in oocytes permitting embryonic development—FLOPED (Ooep) | Two- to four-cell embryo arrest | Cortex | SCMC |
| Maternal antigen the embryos require—MATER (Nlrp5) | Two-cell embryo arrest | Cortex | SCMC |
| Nucleoplasmin 2 (Npm2) | 70% decrease in female fertility, 95% of embryos arrest before blastocyst stage | Nuclear, transient cortical staining during the MII oocyte stage | Maybe SCMC |
| 2′–5′ oligoadenylate synthetase 1d—OAS1D (Oas1d) | 30% decrease in female fertility, 40% of embryos arrest by eight-cell stage | Cytoplasm and cortex | Maybe CPL, MVA, or SCMC |
| Peptidylarginine deiminase 6 (Padi6) | Two-cell embryo arrest | Cytoplasm and cortex | CPL, maybe SCMC |
| Putative maternal effect proteins | | | |
| Cytosolic phospholipase A2γ (Pla2g4c) | NA | Cytoplasm and cortex | Spindle, maybe MVA, or SCMC |
| Developmental pluripotency-associated 5A—DPPA5A (Dppa5a) | Normal fertility due to possible redundancy with KH family members | Cytoplasm | Maybe CPL or MVA |
| NLR family, pyrin domain-containing 14—NLRP14 (Nlrp14) | NA | Cytoplasm | Maybe CPL or MVA |
| Spindlin (Spin1) | NA | Cytoplasm | Spindle, maybe CPL or MVA |
| Transducin-like enhancer of split 6 (Tle6) | NA | Cortex | SCMC |
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