Role of Ethyl Pyruvate in Systemic Inflammatory Response and Lung Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

Table 2

Biochemical parameters and histopathological scores in all groups (mean ± SD).

Parameters	Sh (𝑛=6)	Sh + EP (𝑛=6)	S/C (𝑛=9)	S/C + EP (𝑛=9)
MPO (ng/mL)	81.82±34.21	96.91±49.32	383.85 ± 38.19^a,b	198.33 ± 69.16^a,b,c
MDA (nmol/mL)	1.42±0.43	1.45±0.34	2.95 ± 1.45^a,b	1.96 ± 0.61^a,b,c
TNF𝛼 (pg/mL)	151.63±30.64	147.52±16.14	262.71 ± 18.24^a,b	188.76 ± 56.55^a,b,c
IL-6 (pg/mL)	164.62±16.18	157.98±19.93	196.53±52.22	183.98±56.75
IMA (ABSU)	0.42±0.3	0.32±0.21	0.84 ± 0.43^a,b	0.74 ± 0.22^a,b
Lung MDA (nmol/g)	454.29±35.2	461.63±51.26	522.5 ± 81.12^a,b	499.14 ± 43.2^a,b,c
Lung MPO (ng/mL)	5636.77±404.7	5894.49±971.17	6541.1 ± 613.4^a,b	6019.12 ± 394.4^a,c
W/D weight ratio	2.28±0.18	2.21±0.08	5.55 ± 0.45^a,b	3.77 ± 0.74^a,b,c
Histopathological score	0.5±0.5	0.5±0.4	2.66 ± 0.7^a,b	1.44 ± 0.72^a,b,c

Note: Sh: sham; EP: ethyl pyruvate; S/C: shock/clamp; MDA: malondialdehyde; MPO: myeloperoxidase; TNF𝛼: tumor necrosis factor alpha; IL-6: interleukin-6; IMA: ischemia modified albumin; W/D ratio: wet/dry ratio.
^a𝑃<0.016 versus Sh.
^b𝑃<0.016 versus Sh + EP.
^c𝑃<0.016 versus S/C.