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BioMed Research International
Volume 2014 (2014), Article ID 857329, 11 pages
http://dx.doi.org/10.1155/2014/857329
Research Article

Differences in Brain Transcriptomes of Closely Related Baikal Coregonid Species

1M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, V-437, 117997 Moscow, Russia
2Limnological Institute, Russian Academy of Sciences, Ulan-Batorskaya 3, 664033 Irkutsk, Russia

Received 1 April 2013; Revised 2 October 2013; Accepted 28 October 2013; Published 29 January 2014

Academic Editor: Vassily Lyubetsky

Copyright © 2014 Oksana S. Bychenko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this work was to get deeper insight into genetic factors involved in the adaptive divergence of closely related species, specifically two representatives of Baikal coregonids—Baikal whitefish (Coregonus baicalensis Dybowski) and Baikal omul (Coregonus migratorius Georgi)—that diverged from a common ancestor as recently as 10–20 thousand years ago. Using the Serial Analysis of Gene Expression method, we obtained libraries of short representative cDNA sequences (tags) from the brains of Baikal whitefish and omul. A comparative analysis of the libraries revealed quantitative differences among ~4% tags of the fishes under study. Based on the similarity of these tags with cDNA of known organisms, we identified candidate genes taking part in adaptive divergence. The most important candidate genes related to the adaptation of Baikal whitefish and Baikal omul, identified in this work, belong to the genes of cell metabolism, nervous and immune systems, protein synthesis, and regulatory genes as well as to DTSsa4 Tc1-like transposons which are widespread among fishes.