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BioMed Research International
Volume 2014 (2014), Article ID 858219, 5 pages
http://dx.doi.org/10.1155/2014/858219
Research Article

Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration: Possible Association with Clinical Changes

1IVth Department of Internal Medicine-Hematology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic
2Department of Ophthalmology, Faculty Hospital, Faculty of Medicine in Hradec Králové-Charles University in Prague, Sokolska Street 581, 500 05 Hradec Králové, Czech Republic

Received 10 October 2013; Accepted 22 January 2014; Published 6 March 2014

Academic Editor: Ronald L. Klein

Copyright © 2014 Milan Košťál et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin , a decrease in leukocytes , and an increase in platelets . We found a negative correlation between the amount of platelets and their volume ( , Pearson correlation coefficient: −0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome ( , sensitivity of 76.9% and specificity of 80%). Conclusion. Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).