Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice

Figure 1

Physiological parameters after prolonged cerebral hypoperfusion. (a) Schematic representation of the lateral portions of the corpus callosum (enclosure). (b) Temporal changes in body weight before BCAS (pre) and at days 3, 7, 14, and 28 after BCAS. (c) Proportion of cerebral blood flow (CBF) before BCAS (pre), immediately after BCAS (post), and at days 3, 7, 14, and 28 after BCAS. (d) Temporal changes in blood glucose measured before BCAS (pre) and at days 3, 7, 14, and 28 after BCAS. Data are mean ± SEM of five mice in each group. 𝑃<0.05, ^∗∗𝑃<0.001, compared with the preoperation group (pre). 𝑃<0.05, ^††𝑃<0.001, compared with the same time points. Pre: preoperation.

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