Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice

Figure 5

Serial changes in white matter lesion after prolonged cerebral hypoperfusion in aged groups. (a) Photomicrographs of KB staining in the corpus callosum before BCAS (pre) and at day 28 after BCAS. Scale bars = 200 μm (low magnification) and 20 μm (high magnification). (b) Mean grading score of KB staining. ((c), (d)) Western blotting (c) and densitometric analysis (d) of MBP. Data are mean ± SEM of five mice in each group. ^∗𝑃<0.05, ^∗∗𝑃<0.001, compared with the preoperation group (pre). ^†𝑃<0.05, ^††𝑃<0.001, compared with the same time points. Pre: preoperation.

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