Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice

Figure 7

pCREB expression after prolonged cerebral hypoperfusion in aged groups. (a) Photomicrographs of pCREB staining in the corpus callosum before BCAS (pre) and at day 28. Scale bars = 20 μm. (b) Numbers of pCREB-positive cells in the corpus callosum before BCAS (pre) and at day 28. Data are mean ± SEM of five mice in each group. 𝑃<0.05, ^∗∗𝑃<0.001, compared with the same time points. Pre: preoperation.

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