Mechanotransduction in Musculoskeletal Tissue Regeneration: Effects of Fluid Flow, Loading, and Cellular-Molecular Pathways

Figure 1

Maintaining bone mass as a function of daily loading cycle number requires a certain strain threshold (microstrain). A curve fitting to the data shows daily loading cycle numbers from less than one cycle to greater than 100,000 cycles. The necessary strain to maintain bone mass is reduced as the daily loading cycle number increases.