Cumulative degree and betweenness centrality distributions among DNA, RNA, and retrotranscribing viruses. Host domains that are targeted by DNA, RNA, and retrotranscribing viruses, respectively, have an approximate degree and betweenness centrality: (a) degree distribution and (b) betweenness centrality distribution. These findings are statistically significant by Fligner-Killeen (median) test. The cumulative frequency at a particular value of degree or centrality is the percent of domains whose degree or centrality are less than this particular value. (c) Topological analysis of the human domains and of the human domains targeted by viruses in the human interactome. The mean degree, the mean betweenness centrality, the mean shortest path length, and mean clustering coefficient are given first for all the human domains, then for the human domains targeted by DNA, RNA, and retrotranscribing viruses.
