Phytochemical Screening, Physicochemical Properties, Acute Toxicity Testing and Screening of Hypoglycaemic Activity of Extracts of Eremurus himalaicus Baker in Normoglycaemic Wistar Strain Albino Rats
Table 3
Effect of different extracts of Eremurus himalaicus and glibenclamide on oral glucose tolerance of rats.
Groups
Blood glucose level (mg/dL)
0 min
60 min
90 min
120 min
150 min
Control
81.32 ± 4.44
139.37 ± 5.31
128.37 ± 5.15
120.80 ± 4.65
113.6 ± 4.29
Ethyl acetate extract, 500 mg/kg
81.32 ± 4.26
133.46 ± 5.23
120.19 ± 5.44**
113.79 ± 3.79**
105.76 ± 4.31**
Aqueous extract, 500 mg/kg
83.06 ± 4.93
120.93 ± 2.72*
114.38 ± 2.68*
99.68 ± 6.98*
85.14 ± 3.46*
MeOH extract, 500 mg/kg
84.26 ± 5.08
121.44 ± 7.97*
119.01 ± 4.44**
111.59 ± 5.84**
97.18 ± 5.87*
Glibenclamide, 10 mg/kg
81.93 ± 6.28
112.76 ± 4.00*
103.33 ± 5.49*
89.66 ± 6.57*
75.69 ± 4.38*
Data represented as mean ± S.D values of 6 animals each. * and ** (Dunnett -test); diabetic control was compared with the normal; extract and standard treated groups were compared with the diabetic control.
